Another virulence factor, fimbriae, allows the organism to attach itself to host cells. The sensing of lipopolysaccharides releases an inflammatory cascade in the host organism and has been a major culprit of the sequela in sepsis and septic shock.
A second virulence factor is lipopolysaccharides that coat the outer surface of a gram-negative bacteria.
To date, 77 different capsular types have been studied, and those Klebsiella species without a capsule tend to be less virulent. The polysaccharide capsule of the organism is the most important virulence factor and allows the bacteria to evade opsonophagocytosis and serum killing by the host organism. Virulence of the bacterium is provided by a wide array of factors that can lead to infection and antibiotic resistance. Klebsiella pneumoniae belongs to the Enterobacteriaceae family and is described as a gram-negative, encapsulate, and non-motile bacterium. This activity reviews the evaluation and treatment of patients with Klebsiella pneumonia and the interprofessional team's role in managing patients with this condition. pneumoniae pneumonia is considered the most common cause of hospital-acquired pneumonia in the United States, and the organism accounts for 3% to 8% of all nosocomial bacterial infections. Once the bacterium enters the body, it can display high degrees of virulence and antibiotic resistance. The bacterium typically colonizes human mucosal surfaces of the oropharynx and gastrointestinal (GI) tract. Klebsiella pneumoniae is a gram-negative, encapsulated, non-motile bacterium found in the environment and has been associated with pneumonia in patient populations with alcohol use disorder or diabetes mellitus. Originally named Friedlander's bacillus, it was not until 1886 when the bacterium garnered the name Klebsiella. In 1882, Carl Friedlander first described Klebsiella pneumoniae as an encapsulated bacillus after isolating the bacterium from the lungs of those who had died from pneumonia.
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